In an organization, human resources are known as a valuable and lasting capital. In order to get the most out of these resources, employees' empowerment appeared in the management literature. Empowerment refers to the delegation of authority in order to lay appropriate ground for self-motivation and self-efficacy among employees.The main aim of this study was to explore the effective factors, especially training for employees' empowerment. The statistical population of this study comprised 350 personnel of Center for Medical Documents (CMD), affiliated to the Social Security Organization.The sample consisted of 180 personnel who were randomly selected using sample size formula.The research tool was a self-report questionnaire.The collected data were analyzed using SPSS version 16.The results revealed that among all factors, participative management,organic structure and supportive culture tended to show significant relations with employees' empowerment.The results also indicated that the organization needed to conduct proper short-term and long-term tailored training and to create appropriate ground for financial and spiritual motivation. Accordingly, the study suggests a program for employees' empowerment in CMD.